At present, when ASPxUploadControl is used in Advanced Mode, the number of items within the ASPxUploadControl.UploadedFiles collection will not correspond to the control's FileInputCount property value. In this mode, the ASPxUploadControl.UploadedFiles collection items (UploadedFile objects) will only correspond to non-empty file input elements.
A possible workaround for the current breaking change is demonstrated by the following sample project:
ASPxUploadControl - How to get input indexes for uploaded files on the server side in MulitFile Upload scenario in Advanced mode
In Standard Mode, ASPxUploadControl will work as before.